Some people laugh just to keep from cryin'!
https://www.youtube.com/watch?v=F9R1UhCSyN8"1453" I don't usually make my students memorize a lot of specific dates, but that's one that I usually insist they know.
Not only was it a massive loss of global literature and knowledge because of the destruction mentioned, the scholars who survived fled mostly to Italy, bringing with them some of the saved books as well as knowledge of Ancient Greek (mostly unknown in Medieval Western Europe) and the vast literature and knowledge that this language is the key to.
This was a major spark for what became known later as the Renaissance (though that is a complex and somewhat controversial historical construct, I know).
The closing off of trade routes to the East that the loss of Constantinople represented also meant that people started looking for other routes, which eventually lead to the 'discovery' of the Americas and the age of global piracy and pillage known as the Age of Exploration and Colonialism.
It's about this time that the gun was developed which (along with the long bow and a number of other developments) was eventually to pretty much put an end to the power of the mounted knight so important through most of the Medieval period, and the institutions and literature associated with it.
The printing press was probably in its beta stage at this point, though no mass publishing would happen for a few more years.
This also marks the end of the '100 Years War" (which was actually longer than 100 years, but not completely continuous) between what became France and England, setting the stage for nation states that were to dominate global politics in the modern age, with all sorts of consequences.
I think there are a few other major things happening on or around that time, but that's enough of a history lesson for now!
So maybe just skip that year, and all sorts of things wouldn't have developed that lead to our present pathetic predicament(s)!