I fear a synthetic bug getting out by accident or by design and by gene swapping, enter the human genome and permanently weakening us. We could not stop it from happening. I don't know if there is even a name for such a crime of such import.
To promote the required clinical fastidiousness, the punishment list would have to include everyone along the line from the janitor, coffee-makers, researchers, the lab boss, the directors, the owners or shareholders, the financiers and the customer who initiated the project. No exceptions.
That should get the sane ones to change jobs. Trouble is, the remaining ones will be self-selected pathological optimists, who will be setting the safety standards and doing all the work.